HRAS is an important biomarker that is estimated to drive tumor growth in ~4-8% of patients with advanced head and neck squamous cell carcinoma (HNSCC).1-4 A clinical trial for a novel investigational therapy that targets HRAS activity in advanced HNSCC is underway.
Uncover more for your patients.
HRAS mutations may drive the growth of head and neck cancer cells.
Mutant HRAS Signaling
It’s as easy as using the diagnostic tools that are already available to you.
Early next-generation sequencing can help you determine the best course of action for your patients, including those whose cancer may be driven by HRAS mutations. The HRAS biomarker can be found on commercially available genomic panels, such as:
Unfortunately, many of today’s therapies are suboptimal for most patients.
*Based on patients with recurrent or metastatic HNSCC who progressed on prior therapies in two studies. Outcomes may differ with other treatment regimens such as combination, single-agent, or targeted therapies.
Yes, and your patients with HRAS mutations may be eligible.
There are currently no approved therapies that target HRAS-mutant tumors.3 But advances in the understanding of HRAS have led to further studies, which may provide important insights into the role this oncogene plays in HNSCC.1,2,5 For now, an investigational therapy that targets mutant HRAS activity in HNSCC is being evaluated in a clinical trial.
Patient enrollment is currently open.
1. Castellano E, Santos E. Functional specificity of ras isoforms: so similar but so different. Genes Cancer. 2011;2(3):216-231. 2. Hobbs GA, Der CJ, Rossman KL. RAS isoforms and mutations in cancer at a glance. J Cell Sci. 2016;129(7):1287-1292. 3.Malone E, Siu LL. Precision Medicine in Head and Neck Cancer: Myth or Reality? Clin Med Insights Oncol. 2018;12:1179554918779581. 4. Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517(7536):576-582. 5. Rampias T, Giagini A, Siolos S, et al. RAS/PI3K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma. Clin Cancer Res. 2014;20(11):2933-2946. 6. Kodaz H, Kostek O, Hacioglu, MB, et al. Frequency of RAS mutations (KRAS, NRAS, HRAS) in human solid cancer. EJMO. 2017;1(1):1-7. 7. Mountzios G, Rampias T, Psyrri A. The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact. Ann Oncol. 2014;25(10):1889-1900. 8. Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Regulating the Regulator: Post-Translational Modification of Ras. Nat Rev Mol Cell Biol. 2011;13(1):39-51. 9. Braig F, Voigtlaender M, Schieferdecker A, et al. Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma. Oncotarget. 2016;7(28):42988-42995. 10. Koontongkaew S. The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas. J Cancer. 2013;4(1):66-83. 11. Cohen EEW, Bell RB, Bifulco CB, et al. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC). J Immunother Cancer. 2019;7(1):184. 12. American Cancer Society. Cancer Facts & Figures 2020. Atlanta: American Cancer Society; 2020. 13. Bauml J, Seiwert TY, Pfister DG, et al. Pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: Results from a single-arm, phase II study. J Clin Oncol. 2017;35(14):1542-1549. 14. Ferris RL, Blumenschein G Jr, Fayette J, et al. Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med. 2016;375(19):1856-1867.
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